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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

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206 At typical doses, pyridoxine is readily transported across cell membranes and converted to the active form of B 6 , pyridoxal 5-phosphate (P5P)

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10.1074/jbc.M501269200 74 WarshelA